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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on May 28th, 2009
Women who experience hypertensive pregnancy disorders have significantly increased risk for future hypertension and Type 2 diabetes, report researchers.
Hypertensive pregnancy disorders occur in 5??”7% of all pregnancies, with a higher incidence in women with no previous children, explain Jacob Lykke (Yale University School of Medicine, Connecticut, USA) and colleagues.
As data on the relationship between these disorders and subsequent cardiovascular events is minimal, Lykke and team investigated associations of gestational hypertension and pre-eclampsia with subsequent cardiometabolic complications using data from 782,287 Danish women who gave birth to their first baby (singleton) between 1978 to 2007. A second cohort of 536,419 women who gave birth to two consecutive babies (singletons) in the same time period was also included.
The two cohorts excluded women with previous cardiovascular disease or diabetes. The first cohort were followed up for an average period of 14.6 years and the second cohort for a period of 12.9 years after delivery.
Overall, 43,109 women in the first cohort and 40,450 in the second cohort experienced either hypertension or pre-eclampsia during their pregnancies.
Pooling the data from the two cohorts, the researchers found that gestational hypertension and severe pre-eclampsia increased the risk for subsequent Type 2 diabetes by 3.12- and 3.68-fold, respectively.
In addition, women who experienced these disorders had a much higher risk for subsequent hypertension than women who did not. More specifically, women who had gestational hypertension, mild pre-eclampsia, and severe pre-eclampsia had a 5.31-, 3.61-, and 6.07-fold increase in risk, respectively.
“Physicians and other health care professionals should be encouraged to include the history of a woman’s pregnancy outcomes when estimating the risk of cardiovascular disease,” conclude Lykke et al in the journal Hypertension.
“Identifying these women early will allow for prompt intervention, either primarily as modification of other classical cardiovascular risk factors or secondarily as medical prophylaxis.”
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009
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