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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on June 26th, 2009
Type 2 diabetes and associated complications are not independent risk factors for incident venous thromboembolism (VTE), report researchers in the journal Arteriosclerosis, Thrombosis and Vascular Biology.
Diabetes has previously been reported to be a risk factor for VTE, but John Heit (Mayo Clinic, Rochester, Minnesota, USA) and colleagues hypothesized that this could be because “persons with diabetes are frequently hospitalized for major surgery or acute medical illness, or confined to a nursing home or chronic rehabilitation facility, all of which are major risk factors for incident VTE.”
To test this, the researchers identified all residents of Olmsted County in Minnesota who met criteria for incident VTE over a 25-year period from 1976 to 2000, of whom 1922, aged 64.8 years on average at baseline, were included in the analysis. A group of 2115 controls matched for age, gender, and length of medical history were used for comparison purposes.
Heit and team assessed whether Type 2 diabetes or associated complications such as retinopathy, nephropathy, neuropathy, or ketoacidosis were independent predictors of VTE.
They found that 231 VTE cases and 199 controls had a diagnosis of Type 2 diabetes. Results from univariate analysis showed that, overall, a diagnosis of diabetes was associated with a 32% increased relative risk for incident VTE.
But after adjusting for factors such as hospitalization (including for surgery), acute medical illness, and nursing home confinement, the association disappeared completely.
The researchers therefore conclude that “diabetes mellitus and diabetes microvascular complications are not associated with overall or idiopathic incident VTE.”
They add: “Our findings suggest that the more direct path to reducing VTE incidence is to reduce the need for surgery, hospitalization for acute medical illness, or nursing home confinement among persons with diabetes.”
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009
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