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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on July 15th, 2009
Higher adiponectin levels are consistently associated with a lower risk for Type 2 diabetes in prospective studies of diverse populations, show results of a meta-analysis published in the Journal of the American Medical Association.
Adiponectin secretion is decreased in obesity and low levels of this anti-inflammatory and insulin-sensitizing cytokine are frequently implicated in the development of Type 2 diabetes.
To determine the strength and consistency of the relation between plasma adiponectin and risk for Type 2 diabetes, Rob van Dam (Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA) and colleagues conducted a systematic review and meta-analysis of prospective studies that evaluated adiponectin levels and incidence of Type 2 diabetes.
The authors searched the medical literature up to April 2009 for prospective studies in which adiponectin levels were measured in blood collected before the onset of Type 2 diabetes and which had a minimum follow-up of 1 year.
They identified 13 studies with a total of 14,598 participants and 2623 incident cases of Type 2 diabetes for inclusion in the meta-analysis.
A substantial inverse association between plasma adiponectin level and incidence of Type 2 diabetes was found, with a relative risk for Type 2 diabetes of 0.72 per 1 “log µg/ml increment in adiponectin levels.
This association was seen across diverse ethnic groups, including White, East “Asian, Asian “Indian, African “American, and Native “American populations.
The authors also found that the results did not differ substantially by adiponectin assay, method of diabetes ascertainment, study size, follow-up duration, body mass index, or proportions of men and women.
The research is important as adiponectin levels may be useful for identifying people most likely to benefit from interventions to treat dysfunctional adipose tissue and its metabolic complications, and may in the future be useful for prediction of Type 2 diabetes in addition to established risk factors.
“Although these epidemiologic studies cannot establish causality, the consistency of the association across diverse populations, the dose-response relationship, and the supportive findings in mechanistic studies indicate that adiponectin is a promising target for the reduction of risk for Type 2 diabetes,” conclude the authors.
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009
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