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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on September 01st, 2009
Visceral fat-associated alterations in adipokines may mediate the development and progression of atherosclerosis in people with Type 2 diabetes, Japanese study shows.
Visceral adiposity is reported to be an independent risk factor for coronary heart disease and Type 2 diabetes. Daisuke Koya (Kanazawa Medical University, Uchinada, Ishikawa, Japan) and co-workers conducted a study to simultaneously assess the association between visceral adiposity and vascular parameters in people with Type 2 diabetes.
They recruited 151 patients with Type 2 diabetes and 83 nondiabetic, age-matched controls without atherosclerotic disease.
Visceral fat area was evaluated on a CT scan, and 24-hour ambulatory blood pressure, and serum levels of adiponectin and tumor necrosis factor (TNF)-alpha were measured. The presence of atherosclerosis in the carotid arteries was determined by stiffness index beta, intima??”media thickness (IMT), and plaque formation.
“In addition to an increase in abdominal adiposity, we found that TNF-alpha/adiponectin ratio, HOMA-IR, and serum non-HDL-cholesterol were all higher in the diabetic subjects than in the nondiabetic subjects,” report the authors in the journal Diabetes Research and Clinical Practice.
Comparison of carotid atherosclerosis parameters between the diabetic and nondiabetic individuals revealed a thicker IMT, higher stiffness index beta, and more plaque formation in those with diabetes.
In the patients with diabetes, the determinant factors for each carotid atherosclerosis parameter differed: serum non-HDL-cholesterol was associated with IMT; visceral fat area (probably via an increase in TNF-alpha/adiponectin ratio) with stiffness index beta; and visceral fat area, HOMA-IR, and 24-hour systolic blood pressure with plaque formation. These associations were not demonstrated in the nondiabetic controls.
“Our data show that visceral fat-associated alterations in adipokines might be mediating the development and progression of atherosclerosis in Type 2 diabetic subjects,” conclude the authors.
“Improvement of visceral obesity in Type 2 diabetic individuals could be essential to prevent atherosclerosis,” they add.
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009
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