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Prescription Diabetes Drugs
APOA5 variant increases risk for high triglycerides in Type 2 diabetics]]>
Posted by admin in Prescription Diabetes Drugs on September 28th, 2009
Hypertriglyceridemia associated with high levels of retinal binding protein 4 (RBP4) in individuals with Type 2 diabetes is enhanced in the presence of a variant of the apolipoprotein A5 gene (APOA5), report researchers.
Patients with Type 2 diabetes have an increased prevalence of hypertriglyceridemia compared with nondiabetics, say researchers Luis Masana and colleagues from the Sant Joan University Hospital, in Reus, Spain.
Previous research has shown RBP4 to be “associated with insulin resistance and hypertriglyceridemia in obesity, the metabolic syndrome, and Type 2 diabetes,” say the investigators.
As APOA5 has been suggested to be a “genetic modulator” of triglycerides, the team assessed the relationship between RBP4 concentration, triglyceride levels, and genotype of the APOA5 variant -1131 T/C in 165 Type 2 diabetic patients.
The researchers found that levels of RBP4 were significantly correlated with triglyceride levels and all the components of triglyceride rich lipoproteins in the participants.
No direct link was found between APOA5 -1131 T/C genotype and RBP4 levels. However, carriers of the C allele of -1131 T/C had significantly higher triglyceride levels in the presence of elevated RBP4 levels (at or above the gender-adjusted mean of 43.20 mg/l for men and 37.65 mg/l for women) than TT homozygotes.
More specifically, high RBP4 levels plus presence of the C allele of -1131 T/C increased the risk for hypertriglyceridemia (above 1.69 mmol/l; 149.68 mg/dl) 7.46??”fold.
“The increased RBP4 levels could be considered a consequence of an acquired metabolic disorder acting on lipid- and glucose-metabolic pathways,” suggest the authors. “The presence of the genetic background of the APOA5 -1131 T/C genetic variant would then increase the metabolic actions of RBP4.”
They conclude: “Based on these data, the combination of high RBP4 levels in diabetic patients carrying the unfavorable APOA5 genotype will increase their chances of developing hypertriglyceridemia.”
The results of this study are published in the journal Nutrition, Metabolism and Cardiovascular Diseases.
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009
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