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Posted by admin in Prescription Diabetes Drugs on October 09th, 2009
Plasma angiotensin II is closely associated with body weight and markers of insulin resistance in obese people with Type 2 diabetes, a Japanese study shows.
Many angiotensin-converting enzyme inhibitors have demonstrated metabolic benefits in addition to regulating blood pressure, including a reduction in new onset Type 2 diabetes. To investigate the role of angiotensin II in obesity and insulin resistance, Yoh Miyashita (Toho University Sakura Medical Center, Sakura-City, Chiba, Japan) and co-workers examined circulating angiotensin II levels in 50 obese patients with Type 2 diabetes on a low-calorie weight reduction diet.
The researchers prescribed the participants a diet with a daily caloric intake of 20 kcal/kg for 24 weeks, and measured their levels of plasma angiotensin II and the adipocyte-derived factors leptin, adiponectin, and lipoprotein lipase mass in preheparin serum, a marker of insulin sensitivity.
“In this study, plasma angiotensin II was associated with body weight and decreased after the subjects had been on a 24-week weight reduction diet,” report the authors in the journal Metabolism Clinical and Experimental.
Specifically, participants’ mean body weight and visceral fat area decreased significantly by 2.3% and 7.0%, respectively, accompanied by a significant 24% reduction in angiotensin II levels.
Plasma angiotensin II significantly correlated with body weight both at baseline and at 24 weeks, and the decrease in plasma angiotensin II correlated significantly with the changes in body weight and visceral fat area.
The change in angiotensin II also correlated positively with change in leptin and tended to correlate negatively with change in lipoprotein lipase mass in preheparin serum. Low lipoprotein lipase mass reflects an increase in fat accumulation and insulin resistance.
The mean weight reduction was relatively low compared with other studies following a similar weight-reduction diet. The authors suggest that this may have been a reason why there was no correlation with adiponectin, a marker of insulin sensitivity, implying that plasma angiotensin II is a very sensitive marker during weight loss.
“The close relationship between plasma angiotensin II and the adipocyte-derived factors lipoprotein lipase mass and leptin suggests that circulating angiotensin II is associated with adipocyte metabolism,” the authors comment.
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009
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