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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on February 07th, 2010
Results from a prospective cohort study carried out at a hospital in the Bronx area of New York in the USA suggest that many patients without diagnosed diabetes have abnormally high glycated hemoglobin (HbA1c) levels and are at increased risk for Type 2 diabetes.
“Hospital-based HbA1c testing might identify patients for whom further testing is indicated to make the diagnosis of diabetes,” suggest the researchers.
Charles Nordin (Jacobi Medical Center, Bronx, New York, USA) and colleagues tested HbA1c levels of 971 patients admitted to the general medicine service of a Bronx hospital over a 4-month period.
The team checked records for prior diagnosis of diabetes and other relevant data and followed-up patients who had repeat testing of HbA1c or glucose within 1 year of admission.
The Bronx area has a diabetes prevalence that is one of the highest in the USA and in line with this 342 (35.2%) patients tested had diabetes.
A normal HbA1c is generally considered to be below 6%. The mean HbA1c of the remaining cohort (n=629) was 6.05%. Of these patients, 152 (24%) had an admission HbA1c of at least 6.5% and 62 (9.9%) had an HbA1c of at least 7.0%.
In total, 55 of the patients with an admission HbA1c of at least 6.5% had a follow-up HbA1c test within 1 year, at which point 44 (88%) patients met the criteria for diabetes proposed by The International Expert Committee using repeated HbA1c testing.
“Our study supports the hypothesis that HbA1c testing on the inpatient service of a public hospital in a high-risk community can help to identify patients at risk for diabetes,” conclude the authors in the Journal of Clinical Endocrinology and Metabolism.
The researchers caution that use of single HbA1c measurements for diagnosing diabetes is unwise as factors such as hospital admission can significantly influence HbA1c levels.
They add: “Further studies will be needed to determine the role of inpatient HbA1c testing for diagnosis and treatment of diabetes.”
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010
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