The Brd2 gene is a promising new target in diabetes prevention. Researchers succeeded in preventing diabetes in high risk groups by inhibiting the expression (or activation) of the gene. Activating the gene seems to trigger sugar cravings and promote hunger, in order to meet the brain’s high energy demands.

It’s believed that the Brd2 gene is very active in high risk individuals. Influencing the activity of genes like Bdr2 is a promising new genetic target for diabetes prevention.

Researchers studying the gene concluded, “The strong influence of Brd2 on insulin resistance suggests that inhibiting Brd2 is a promising target for diabetes prevention and treatment.”

A New Field in Diabetes Prevention

The study of nutrients that influence gene expression is a promising new field in diabetes prevention, called nutrigenomics. It’s basically a natural form of gene therapy.

But unlike conventional gene therapy that chemically alters the DNA, nutrigenomics influences how a gene is expressed. Nutrients are used to turn genes on or off, depending on the desired effect. It’s a safe and effective method in disease prevention and treatment.

By inhibiting the Brd2 gene, nutrigenomics succeeds where conventional treatments fail…preventing sugar spikes, improving fasting glucose levels, and restoring insulin sensitivity.

How to Inhibit the Brd2 Gene

The best way to inhibit the Brd2 gene is to keep it turned off. This is possible if you avoid three metabolic states believed to activate the gene…

1. Fasting

Fasting for just 4 hours reduces the supply of constant energy required by the brain. The energy deficit activates the Brd2 gene leading to sugar cravings. This is why breakfast and eating several times throughout the day are so important.

2. Chronic Stress

Chronic stress saturates your body with adrenaline. The effect on the brain is dramatic. Brain cells start to fire like crazy, depleting energy supplies.

Needing more energy to manage the stress, the brain activates the Brd2 gene. This is why carbohydrates are comfort foods.

The quick energy that sugar provides keeps you level headed and helps you deal with the stress. But relief is temporary. Eating sugar eventually releases more adrenaline which further activates the Brd2 gene.

3. Systemic Inflammation

A typical Western diet is load with processed foods that damage cells and tissues, triggering inflammatory reactions. Systemic inflammation is a physical stress effecting the entire body.

The body responds to any type of stress by releasing adrenaline. As you learned about, adrenaline activates the Brd2 gene.

But it gets worse…

Inflammation prevents feeling “full.” Together with an active Brd2 gene, it keeps you hungry and craving dangerous carbohydrates.

Diabetes Prevention with Nutrigenomics

Target gene expression and protect against diabetes with nutrigenomics. Integrate the strategies below into your diabetic diet for preventing Brd2 gene activation.

1. Directly inhibit Brd2 activation with 200 mg/day of this potent antioxidant.

2. Learn the number of daily meals and healthy percentage of calories to avoid prolong fasting.

3. Learn when to eat breakfast (and what to eat) for breaking the overnight fast.

4. Supplement with green tea’s most powerful nutrient for stress relief.

5. Supplement twice a day with the most effective dose of omega-3 fats for easing inflammation.

6. Learn about the West African plant that controls hunger all day long.

7. Supplement with pine nuts for additional hunger control.

Have you been monitoring your blood sugar level for a while? Are you disturbed as your blood glucose levels are tricky? I know that a dangerous blood sugar level reading look fine if you have eaten several slices of cakes at your friend’s birthday party. However the things does not seem fine if you get a higher reading even after eating a low carb and high protein meal. What worse if the reading is high even after exercising the previous night?

If you are facing the same scenario then you must spend here few minutes to know what is actually going on within you. Let’s dig in to find out more.

I’m sure you know that exercise and diet affects the sugar level in blood. You may be unaware there are certain other things like virus or stress that affects the blood glucose level at the same time. A higher reading may also come up as with the regular usage and passage of time, your medication is no longer affecting your body system properly. A single higher reading is nothing that you should worry about. However if you notice a pattern or series of high readings then it is important to consult your health care professional.

It is the responsibility to check the sugar level in blood if you are a diabetic. Unluckily the monitoring of blood glucose level is like a two-edged sword. Studies have revealed that recurrent monitoring generally results in the feeling of “failure” or “success” for diabetics. If the results are becoming consistently higher then it may trigger the feeling of self blame and anxiety.

Sometimes these feelings cause some diabetics to give up blood glucose monitoring. The important here is to understand that blood glucose monitoring is not a test but a tool to fight against this deadly disease.

So if ever your blood glucose level results are higher you should

* Test again before meal and then two hours after meals. This will help you to check how well your medications are working for controlling the blood sugar level. It will also help you to understand which foods are boosting the levels of sugar in blood.

* Define the patterns of blood glucose readings. If the levels are higher one day then there isn’t any big deal. However repeated high levels of sugar in blood must be discussed with doctor.

* Start taking baby steps. Try some more exercise or limit the amount of carbohydrates in your next meal. Never go overboard. If ever a pattern is seen for more than three days consult your physician.

* Relaxing is best for controlling blood sugar levels. It is not only the food that converts blood glucose level in a roller coaster. If there are dangerous blood sugar levels on your glucometer then it is the right time to relax.

* Try to build a friendly relationship with your doctor. Even after doing all this you are unable to control blood sugar levels then discuss with your doctor. He is able to see the bigger picture. Sometimes with the passage of time the pancreatic cells stop to produce insulin, sometime the particular medicine becomes ineffective. Doctor’s suggestion can be of great help to you.

A group of diseases that affect how your body uses blood glucose is known as diabetes mellitus. Chronic conditions are type 1 and type 2 diabetes. The reversible conditions are gestational diabetes and pre-diabetes. Gestational diabetes occur during pregnancy and pre-diabetes is when your blood sugar levels are higher than normal but still not high enough to be classified as diabetes.

There is no known exact cause of type 1 diabetes known to scientists. It is proven that the immune system that protects and fights off harmful bacteria and viruses, mistakenly destroys the cells that produce insulin in the pancreas. This insulin is also known as islet. No matter what the cause of your diabetes, rather it be genetic or triggered by a virus, once the islet cells are destroyed, your body will produce little or no insulin. Type 1 diabetes was also known as juvenile diabetes although it usually appears during adolescence but can develop at any age.

If you have any type of diabetes, your blood has too much glucose. Glucose is vital because it is the body’s main source of energy that fuels your tissue and muscles.

Normally, cells get energy to the body’s muscles and tissues by getting glucose in them from the help of the hormone insulin. The pancreas produces insulin and is located just behind the stomach. When your body is working properly, after eating, insulin will secrete from the pancreas into your bloodstream. Then it circulates and acts like a key unlocking tiny doors that allow sugar to enter into cells. Insulin lowers the amount of sugar in the bloodstream dropping the sugar levels and the secretion from the pancreas.

Our livers act as a manufacturing center that stores glucose. If you haven’t eaten in a while, your insulin levels can get low triggering the liver to convert stored glycogen back to glucose to keep your levels within a normal range. This doesn’t occur with type 1 diabetes, there is no insulin to put glucose into your body’s cells. This causes sugar to build up in your bloodstream, when it should be transported to the cells. When this occurs, it can be life threatening.

The more familiar type 2 diabetes has a different cause. It was once known as adult-onset or non-insulin dependent diabetes, a chronic condition that affects the way your body metabolizes sugar. Islet cells still function, but the pancreas doesn’t produce enough insulin or it becomes resistant to it. There is no cure for type 1 or type 2 diabetes, but it is preventable and manageable. You can start with a healthy diet, exercising and maintaining your weight. You still may need insulin therapy or diabetes medications. Your weight and diet should always be managed, even if you are on medications or insulin.

Your feet are abused daily and most people take them for granted until a real issue arises. Common problems include dryness, redness and cracking which can be attributed to improper care maintenance. If you have diabetes, it is very important you keep on top of any foot issues. Diabetes affects nerve endings in your feet which minimize the body’s ability to determine damage and pain. If issues go unchecked or untreated, severe complications can occur due to infection.

Some common foot ailments that appear on the foot are:

1. Calluses - A callus is typically hard skin tissue that has built up over time. The areas most likely to have calluses are on the soles of the feet. Usually, a callus occurs when shoes are do not fit well and weight is not distributed evenly across the foot. If you have calluses, the best course of action is to rub down the extra tissue with a pumice stone after you bathe. Do not try to cut the skin away from the foot as an infection may occur.

2. Corns - Corns are similar to calluses except they appear near bony areas around the toes. Corns appear as a result of extended pressure between or around the toe due to improper shoe wear. As with the typical callus, corns can be removed by rubbing them down with a pumice stone after bathing.

3. Bunions - Bunions are areas of the big toe that become red and sensitive because they are pushed toward the inside toe. Usually this is the result of wearing high heeled shoes if you have narrow toes. Common padding can be used to help relief pain, irritation and potential infection, but surgery may be necessary to re-align the toes to their proper positions. Bunions can occur in one or both feet.

In summary, proper sizing of your footwear is important in keeping your feet healthy. If you are dealing with diabetes, it is very important to deal with minor issues before they become out of control and infectious. Infections can lead to real issues, especially if diabetes is part of the equation. Diabetes can interfere with the body’s ability to fight infection which could lead to real problems.

Feet are abused daily and everyone takes them for granted. They are the ugly step children who rarely get noticed or attended to unless a major issue occurs. Usually, the only time they get any attention whatsoever, is to paint and trim the toenails. If you are guy, toenail trimming can be few and far between.

Common problems can occur with cracking, soreness and itching. Usually this means a fungal infection has established residence on the sole or between the toes. Burning itching and peeling can become annoying and even painful.

Athletes Foot is usually the culprit and can be most common in people who swim or shower in public areas. Common within sports enthusiasts, athlete’s foot is a fungus that infects the feet and causes itching, peeling and redness, especially around the toes. Over the counter topical medication can be applied as treatment. If the area does not get any better, oral medication prescribed by a doctor may be in order.

The toenail can be another area that fungal infections can take place. If one or more of your toe nails become discolored or abnormal; a fungus may be the cause. In some cases, the nail becomes yellowish an opaque. After awhile the nail becomes brittle and can even separate from the toe itself. Immediate attention is needed to treat the area with topical or oral medication may be needed. Toe fungus is difficult to treat so it is important to address this right away.

If you have diabetes, it is highly important you keep on top of fungal issues. Your feet should be inspected daily and proper care and maintenance is highly recommended. This includes regular cleaning, inspection and treatment of cuts, sores and fungal infections. If an infection goes untreated, serious issues can occur down the road.

If you have ever been told that type II diabetes in incurable and that you will be taking medication for the rest of your life, then I need you to know that thousands are ridding themselves of this disease and you can too. Are you willing?

In this documentary experiment for all to see these 6 participant all with type II diabetes (Actually two had type 1) was able to get off medication and insulin within the first week. They all lost weight, lowered cholesterol increased energy levels, and was able to beat there disease.

At the end of the 30 day program all but one, was off of all insulin and other medication, and had a normal blood sugar level even after every meal, they all lost weight, reduce your cholesterol and increase their energy levels all at the same time. What did they do?

Well as I said earlier this was a very radical program. It was designed to take someone from being a type2 diabetic to being completely cured in on the 30 days.

The participants in this program went on a raw food vegan diet for 30 days, the amazing thing is that most of them were able to normalize their blood sugar level and get off of insulin and their other medication within the first eight days of the program. This was amazing! Of course they were not required to remain on this raw vegan diet for the rest of their life.

This was just taking drastic measures to combat a drastic situation. But the point of the documentary was to show that your lifestyle, what we eat and what we drink can either heal us or make us very sick. Type II diabetes is a lifestyle disease, and with some radical changes in your diet, along with exercise can in fact reverse this disease.

Of all the 6 participants in the 30 raw diet cure your diabetes program all but two was successful at curing themselves or diabetes at the end of the 30 days. The only reason why two were not successful is because one left after the second week, even though he had by this time normalized his blood sugar levels, lowered his blood pressure, lowered his cholesterol to normal levels lost 20bls, got of all of his 17 medication, he decided to leave because he did not like the raw food. The very food that was curing his and making his well in more ways than one he rejected.

The other person who had great results by cutting back his insulin shots from 120cc to 5cc a day was type 1 diabetes but drank alcohol the entire time he was in the program and did not stick with the diet completely. It is important to note that there was another type 1 diabetic in the program who by the end got off all medication and insulin.

It is just amazing how much or what we eat can do to our bodies, and how much our medical industry plays down this powerful proven method.

Eating the proper foods can have a medicinal effect on our systems, we just have to know what to eat and when to eat it.

Is it really possible to cure type II diabetes in thirty days with diet and exercise? Well the results speaks for themselves.

Six individuals from all walks of life came together to try a program that fed them raw vegan food for thirty days in order to get rid of diabetes. After the 30 days, those who stuck with the program did in fact reverse diabetes and was able to get off all medications and insulin.

Once the thirty days are over then what? Well most of them and I would guess most diabetics out there would have to re-learn how to chose, prepare and eat the foods that are in the best interest of their body.

This entire re-education is important because every think you put in your mouth has an effect, good or bad. I because a vegetarian, and then a vegan over 10 years ago and have never looked back. I do not miss flesh foods and the smell now makes me sick. To think I was a big heavy meat eater as I was into the food and beverage industry and worked as a chef for 25 years before becoming a vegetarian, so if I can do it I know anyone can.

You do not need to become vegan in order to cure your type II diabetes, but you will have to make some radical changes in your lifestyle and eating habits to be able to achieve the results you need.

At least a 80% plant based diet high in fiber and very low in fat and oils is what’s needed to succeed. Out of that 80% of plant based food 70% should be raw, or uncooked. Cooking foods changes the chemical make up of foods and kills the essential, life giving nutrients and enzymes in he food.

Reducing the fat and oils from the diet will in turn reduce the fat that reaches the into the blood stream and liver. This will gradually restore the sensitivity of the cells in the body to insulin, which will help in the transfer of sugar into the cells. The result are usually quick and dramatic. By just reducing your fat intake by just 10% of your daily caloric intake, a type II diabetic can reduce and normalize blood sugar levels to normal in just 6 - 8 weeks.

A Diet high I plant base fiber is important because it will help to regulate the release of sugars into the blood stream which causes the high and low, spike and dips in your insulin production.

The more dramatic is your change, the more dramatic the results. The news is getting around and there are thousands of former diabetics who are able to get rid of all there medication and in fact live a normal life.

Exercises should also be added to the routine and most be consistent and regular. A brisk walk is all is needed to help reduce your weight and help to burn up the fat that is in the body. Overweight and obesity is a major cause of type II diabetes.

Take charge of your health starting today and you can be diabetes free in as little as 30 days.

A few basic tools are what you need to achieve good self-management of your type 2 diabetes. These tools will need to include changes in how you manage you lifestyle, maybe medications and regular self-monitoring of your blood sugar levels.

Being diagnosed with type 2 diabetes can definitely be classed as stressful… maybe you had no idea you had a diabetic predisposition; you were not aware anyone in your family also had this condition. One of the first aspects of self-management that you may chose to integrate into you life will be stress management… almost everyone feels stressed when they are first diagnosed. No-one wants to think about changing their lifestyle!

How far you take the concept of self-management is entirely up to you but to start with, the aim of self-management is to:

• help you feel physically and emotionally better
• improve the overall quality of your life
• keep you as healthy as possible in the years ahead

What does self-management consist of? Well primarily it means:

• educating yourself
• monitoring your medical condition
• working with your health care team in order for you to adapt to your various lifestyle changes

The first few weeks following diagnosis may be more than you can bear… it may feel kind of impossible. But it doesn’t need to be that way. At first it will be time consuming learning “a whole new language” and it may frustrate you. But really, self-management means overcoming some of your indulgences, those impulses you have allowed to almost rule your life and to some degree, spoil your health.

After a while, many of the things you do will become as routine as cleaning your teeth. Self-management really only means learning what to do and when to do it… when to apply that knowledge to control your type 2 diabetes, your weight and your blood sugar levels.

Five Steps of Self-Management includes:

1. Blood sugar testing or self monitoring: this is linked to all aspects of type 2 diabetes… your health care provider will instruct you re techniques and set an ideal blood sugar level target for you

2. A healthy eating plan: this means a new style of eating that concentrates on healthy foods in reasonable amounts

3. Physical activity: increasing physical activity is something that will help you immediately and in the long term. Physical activity or exercise has the same effect as insulin, it helps move blood sugar into your muscle cells

4. Medication may be prescribed by your health care provider if immediate benefits are needed

5. Stress management: stress raises your blood sugar levels which harms your body over time. Stress relief is useful to everyone.

By educating yourself, practicing what you learn and asking for appropriate advice when necessary, you can manage your type 2 diabetes.

Every year thousands of people are diagnosed with diabetes in the United States. Diabetes is a medical condition where the body is unable to produce or use insulin correctly. Insulin is the hormone in charge of converting sugar, starches and other food into energy. Diabetes is often caused by genetics, obesity and a lack of exercise.

Recently, many doctors have begun to prescribe yoga to patients diagnosed with diabetes. Research has shown yoga is an effective form of treatment to help manage diabetes and cope with mental stress which often accompanies the obesity experienced with the disease.

The yoga lifestyle is not just based on exercise; it also promotes a healthy diet and regular meditation. By practicing these two principles with regular scheduled yoga sessions, an obese person will lose weight, and become more comfortable with their condition.

Yoga helps a person deal with who they are as an individual by preparing their mind for meditation. Meditation reveals insight into what we need and allows us to accept all our problems for what they really are. This quiet method of “going within” eventually helps us find answers to accept and appreciate our unique life.

Yoga will balance the endocrine system, strengthen the abdominal muscles, and stimulate the nervous and circulatory systems. By practicing yoga you will have an effective strategy to strengthen your fight against diabetes. You may not ever beat diabetes but you can lessen the effects on your physical, mental and emotional well being with a stronger body, better immune system, and a peaceful heart. Natural Wellness Techniques.

Around one in 12 US adults have impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), plus at least one other cardiometabolic risk factor, and should be considered for metformin treatment to prevent Type 2 diabetes, say US researchers.

“Diabetes is a public health epidemic associated with high morbidity, mortality, and cost,” comment Mary Rhee (Emory University School of Medicine, Atlanta, Georgia) and team.

Of those with pre-diabetes, IFG and/or IGT, 25 “40% will go on to develop Type 2 diabetes if left unchecked. This can be prevented or delayed through lifestyle change and/or treatment with medication such as metformin, and the American Diabetes Association (ADA) recommends early identification and treatment of high-risk individuals.

The researchers assessed risk factors in 4706 individuals from the Screening for Impaired Glucose Tolerance study, Third National Health and Nutrition Examination Survey, and National Health and Nutrition Examination Survey 2005 “2006.

ADA criteria for suitability for metformin therapy are the presence of both IFG and IGT plus at least one additional risk factor for diabetes including: age below 60 years, body mass index of 35 kg/m² or below, family history of diabetes, high triglycerides, low high-density lipoprotein (HDL) cholesterol, hypertension, or high glycated hemoglobin.

Across the three studies, 8.2 “9.4% of the participants had both IFG and IGT, 18 “22.3% had IFG alone, and 5.0 “7.2% had IGT alone.

As reported in the journal Diabetes Care, the researchers found that across the three studies, 96 “99% of the individuals with both IFG and IGT met the ADA criteria for metformin therapy.

The authors say that their results indicate that “once the presence of both IFG and IGT has been established, the presence of additional risk factors could almost be assumed, and initiation of metformin should be considered.”

They conclude: “To the extent that our findings are representative of the US population, around one in 12 adults has a combination of pre-diabetes and risk factors that may justify consideration of metformin treatment for diabetes prevention.”

MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

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