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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on April 27th, 2010
Around one in 12 US adults have impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), plus at least one other cardiometabolic risk factor, and should be considered for metformin treatment to prevent Type 2 diabetes, say US researchers.
“Diabetes is a public health epidemic associated with high morbidity, mortality, and cost,” comment Mary Rhee (Emory University School of Medicine, Atlanta, Georgia) and team.
Of those with pre-diabetes, IFG and/or IGT, 25 “40% will go on to develop Type 2 diabetes if left unchecked. This can be prevented or delayed through lifestyle change and/or treatment with medication such as metformin, and the American Diabetes Association (ADA) recommends early identification and treatment of high-risk individuals.
The researchers assessed risk factors in 4706 individuals from the Screening for Impaired Glucose Tolerance study, Third National Health and Nutrition Examination Survey, and National Health and Nutrition Examination Survey 2005 “2006.
ADA criteria for suitability for metformin therapy are the presence of both IFG and IGT plus at least one additional risk factor for diabetes including: age below 60 years, body mass index of 35 kg/m2 or below, family history of diabetes, high triglycerides, low high-density lipoprotein (HDL) cholesterol, hypertension, or high glycated hemoglobin.
Across the three studies, 8.2 “9.4% of the participants had both IFG and IGT, 18 “22.3% had IFG alone, and 5.0 “7.2% had IGT alone.
As reported in the journal Diabetes Care, the researchers found that across the three studies, 96 “99% of the individuals with both IFG and IGT met the ADA criteria for metformin therapy.
The authors say that their results indicate that “once the presence of both IFG and IGT has been established, the presence of additional risk factors could almost be assumed, and initiation of metformin should be considered.”
They conclude: “To the extent that our findings are representative of the US population, around one in 12 adults has a combination of pre-diabetes and risk factors that may justify consideration of metformin treatment for diabetes prevention.”
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010
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