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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on May 07th, 2010
Patients with diabetes are at increased risk for various pulmonary conditions, but not lung cancer, report researchers.
Samantha Ehrlich (Kaiser Permanente Northern California, Oakland, USA) and colleagues carried out a retrospective, longitudinal cohort study of participants of a large healthcare plan in California. These included 1,733,591 members without diabetes (median age 43 years) and 77,637 members with diabetes (median age 60 years).
The participants were followed-up from 1996 until 2005 or until diagnosis of asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, pneumonia, and lung cancer, or death, or termination of membership of the Kaiser Permanente Medical Care Program.
As reported in the journal Diabetes Care, the researchers found that the incidences of asthma, COPD, pulmonary fibrosis, and pneumonia were a significant 8%, 22%, 54%, and 92% higher, respectively, in diabetics compared with nondiabetics.
In addition, they observed a significant 3% and 6% increased relative risk for COPD and pneumonia, respectively, with each unit increase in baseline glycated hemoglobin (HbA1c) for participants with diabetes. This association was not seen for asthma or pulmonary fibrosis.
Of note, no significant difference in the incidence of lung cancer was observed between diabetics and nondiabetics.
“The observed association between diabetes and COPD in the present study might be explained by the increased occurrence of pneumonia in patients with diabetes, as well as decreased pulmonary function related to hyperglycemia,” suggest Ehrlich et al.
“Future studies examining the risk of these pulmonary conditions among patients with and without diabetes could benefit from a prospective design that includes repeated measurements of smoking, alcohol consumption, body mass index, and physical activity over time,” conclude the team.
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010
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