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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on May 30th, 2010
Diabetic retinopathy is associated with visceral fat accumulation and insulin resistance in patients with Type 2 diabetes, study results show.
Futoshi Anan (Oita Red Cross Hospital, Japan) and co-workers explain that “increased visceral fat accumulation is a risk factor for cardiovascular disease and is associated with insulin resistance in healthy subjects and patients with Type 2 diabetes mellitus.”
Furthermore, the researchers add that “the presence of diabetic retinopathy is reported to be associated with insulin resistance in Type 2 diabetes mellitus patients.”
Based on these observations, Anan and team hypothesized that increased severity of diabetic retinopathy is associated with visceral fat accumulation and insulin resistance in patients with Type 2 diabetes mellitus.
The scientists studied 31 patients with Type 2 diabetes and 71 patients with both Type 2 diabetes and diabetic retinopathy, all of whom were Japanese.
Analysis of visceral fat levels and insulin sensitivity revealed that the risk for diabetic retinopathy was significantly, positively, and independently predicted by visceral fat accumulation and degree of insulin resistance. These associations remained after controlling for potential confounders, including age, gender, body mass index, waist circumference, duration of diabetes, hypertension, dyslipidemia, blood pressure, and lipid concentrations.
The authors concede in the journal Metabolism: Clinical and Experimental that their study is limited because none of the patients underwent coronary angiography and so the potential influence of cardiovascular disease on the relationships between visceral fat accumulation and retinopathy could not be accounted for.
However, despite these and other limitations, they conclude that the findings provide early evidence for links between diabetic retinopathy and elevated levels of visceral fatty acid accumulation and insulin resistance, which deserves further study.
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2009
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