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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on September 23rd, 2010
Study results show that patients with diabetes have a significantly weakened cardiac response to exercise compared with nondiabetics.
“Clinical studies have shown that limitation in exercise capacity is a strong predictor of cardiovascular and all cause mortality in diabetic patients with heart failure,” report researchers in the journal Heart.
Chaitanya Dutt (Torrent Research Centre, Gandhinagar, Gujarat, India) and team therefore investigated changes in cardiac function and microvascular utilization during exercise in 31 diabetic individuals with glycated hemoglobin (HbA1c) above 8% and 38 age-matched nondiabetic controls.
The participants completed in a 10-minute exercise test on an exercise bike at a constant load of 50 Watts preceded by a 10-minute acclimatization period and followed by a 15-minute recovery period.
Cardiac function was continuously monitored by the researchers using impedance cardiography, and regional flow and oxygen function by laser Doppler and white light spectroscopy.
The researchers found that the diabetic participants had significantly reduced cardiac reserve, reduced capacity to increase cardiac output to the maximum during exercise, increased cardiac overshoot, and slow return to resting baseline cardiac output during recovery compared with the nondiabetics. This was mainly due to a reduction in ability to increase stroke volume.
In diabetics there was a simultaneous attempt to maintain adequate regional microvascular perfusion by increasing blood flow to the exercising muscle. However, the blood supply reaching the muscle was more desaturated in diabetics compared with normal individuals.
In addition, the cardiac reserve reduction and regional oxygen delivery during exercise were found to be related to diabetes severity.
“This study shows that cardiac response to exercise is attenuated significantly in diabetic individuals,” conclude Dutt et al.
“These changes could be the harbinger of reduced exercise capacity in diabetics,” they add.
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2009
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