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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on November 24th, 2010
Study results show that atrial fibrillation (AF) develops faster and is significantly more prevalent in individuals with diabetes compared with nondiabetics.
The findings, presented at the European Association for the Study of Diabetes’ 45th Annual Meeting in Vienna, Austria, also showed that the presence of diabetes in women imparted a greater relative risk for AF than in men.
“Men with diabetes are also at higher risk, but the association between the two conditions is not as strong. For men, obesity and high blood pressure are bigger risk factors from diabetes,” said lead researcher Gregory Nichols from Kaiser Permanente Center for Health Research in Portland, Oregon, USA.
Nichols and colleagues used data from the Kaiser Permanente Northwest electronic medical record database to select 17,372 patients, aged 58.4 years on average, who were enrolled in a diabetes registry before the end of 2004. An equal number of gender- and age-matched nondiabetic controls were selected from the same database.
The participants were then followed up until they died, left the health plan, or until the end of December 2008 for incidence of AF. At baseline, 631 (3.6%) diabetics compared with 442 (2.5%) nondiabetics had AF.
The general prevalence of AF increased with age in both groups, but to a much greater extent in those with diabetes. Over an average of 7.2 years of follow-up, the age- and gender-adjusted incidence rate of AF in those without previous AF was 9.6 per 1000 person-years in diabetics compared with 6.9 per 1000 person-years in controls.
This amounted to an increased relative risk for AF of 39% in patients with diabetes compared with controls, although this was reduced to an 18% increased risk after adjusting for various potential confounding factors.
The team also found that, despite men being at generally higher risk for AF than women, among diabetics only women had a statistically significantly increased risk for AF of 26% compared with a nonsignificant 9% increase in risk for men with the condition. “By virtue of having diabetes, the protective effect of being a woman seems to be removed,” commented Nichols.
The results from this research are also published in the October issue of the journal Diabetes Care.
Summing up their findings, co-author Sumeet Chugh (Cedars-Sinai Medical Center, Los Angeles, California, USA) remarked: “AF is the most common arrhythmia in the world, and diabetes is one of the most common and costly health conditions. Our study points out that there is a connection between these two growing epidemics ??” one we should pay closer attention to, especially among women.”
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2009
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