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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on March 11th, 2011
A weight-loss program combining diet, exercise, and telemonitoring, and only moderate cost can offer multiple benefits for patients with Type 2 diabetes, a small trial suggests.
The Active Body Control (ABC) program significantly lowered body weight, glycated hemoglobin (HbA1c) levels, and the use of anti-diabetic drugs during a period of 6 months compared with standard therapy.
Sabine Westphal and co-workers from the Otto-von-Guericke-University Magdeburg in Germany, randomly assigned 70 overweight patients with Type 2 diabetes and a mean age of 57.5 years to the ABC program or standard therapy.
ABC participants were advised to lower their calorie intake by 500 kcal/day and preferentially consume low GI-carbohydrates, as well as increase their physical activity. Telemonitoring of weight and physical activity was also conducted, with a weekly feedback letter to inform and motivate participants. The cost to the patient of the ABC program was €150 (US $196).
After 6 months, patients on the ABC program had lost a statistically significant mean of 11.8 kg in weight versus no significant change for those on standard therapy.
Glucose levels in ABC patients decreased by 1.0 mmol/l and HbA1c levels by 0.8%, with respective reductions of just 0.2 mmol/l and 0.2% with standard therapy.
The proportion of patients with HbA1c of more than 7% fell from 57% to 26% with the ABC program, but increased in the standard-therapy group. Antidiabetic drugs were discontinued in 39% of the ABC group and reduced in 42% versus far smaller changes with standard therapy.
Reporting in the journal Diabetes Research and Clinical Practice, the researchers summarize: “The ABC program combines innovative telemonitoring with additional sensible measures.
“In obese diabetic patients it leads not only to a pronounced weight loss but also to relevant metabolic improvements and reductions in antidiabetic drug use.”
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010
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