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Prescription Diabetes Drugs
What You Should Know About Diabetes
Posted by admin in Prescription Diabetes Drugs on April 30th, 2011
Whenever I inform my patients that they may be suffering from juvenile diabetes, better known as Type 1, the reaction is often the same. “How can I have juvenile diabetes when I am not an adolescent?” This is a very good question and one worth explaining.
Although juvenile diabetes tends to occur in young, lean individuals, usually before the age of 30, older people may also show signs of this chronic condition. What’s worse is that approximately 12 million people in the United States have diabetes and don’t even know it! The reason for this astounding statistic is that the American Diabetes Association does not recommend screening for the general population at this time unless you have a parent or sibling with the disease.
With an estimated 17 million people (about 8 % of the population) in the United States affected with diabetes it is important for everyone to have a better understanding of this insidious disease.
There are many factors that play into the cause of type 1 diabetes including genetics and exposure to certain viruses. Diabetes is considered to be a chronic condition meaning that it lasts a lifetime. Despite ongoing research no known cure has been found to date, but type 1 diabetes is manageable and treatable. People suffering with diabetes are now living longer, healthier lives with the addition of herbs and nutritional supplements available to complement conventional medicine.
All About Blood Sugar
Glucose is a simple sugar found in food and is a necessary nutrient that provides energy for the cells to function properly. Glucose in digested food cannot enter the cells without the help of insulin to help it along. Without it, the cells become starved of glucose energy and the unused sugar is wasted in excreted urine. That’s why a urine test is sometimes used as a means to measure sugar levels in the body and to check for potential signs of diabetes.
A person with type 1 diabetes doesn’t produce enough of the hormone insulin or is unable to use it effectively, which causes high blood sugar (glucose) levels. Over time, this imbalance can lead to heart disease, nerve damage, kidney disease, vision loss, and other complications. The less controlled your blood sugar, the higher the risk of disabling complications over a long period of time.
As a type 1 diabetic, the goal is to keep your blood sugar level as close to normal as possible to delay or prevent complications. This is done by monitoring blood glucose levels and is the only way to make sure that your sugar level remains within the target range.
You should also include a healthy diet of fruits, vegetables, and whole grains. These foods are high in nutrition and low in fat and calories. Fewer sweets and animal products provide more nutrients and less sugar.
Move to Keep Blood Sugars Low
If you are a type 1 diabetic, the secret to lowering blood sugar is more than just a healthy diet. Exercise is right up there with watching what you eat. The advantage of physical activity is that it moves sugar from your blood into your cells so the more you move the lower your blood sugar level.
Walking, biking, and swimming are examples of activities that you might enjoy and can easily be included in your daily schedule. Shoot for at least 30 minutes of aerobic exercise as many days of the week as possible. Add some weight bearing exercises along with stretching to round out your program. Remember not to do too much too soon especially if you have not exercised for awhile. Consult your doctor for advice on the level of physical activity that is best for you.
Type 1 diabetics must also be cautious of their blood sugar dropping too low especially when taking insulin. When blood sugar drops the condition is known as hypoglycemia and is common among diabetics as well as people who are not.
Nature Can Help You Live with Type 1 Diabetes
The majority of people with type 1 diabetes are insulin dependent. But did you know there are natural remedies that have been around for years proven to be effective in lowering blood glucose levels? Here are a few of nature’s miracle workers:
?Gymnema sylvestre - The name of this herb actually means “destroyer of sugar” and was used in ancient times as a treatment for diabetes. “A study published in Ethnopharmacology in 1990 showed a daily dose of 400 milligrams was effective in lowering blood glucose levels in diabetics over the long term.”
?Fenugreek - A popular herb used for high blood sugar and lowering cholesterol.
?Bitter Melon (Momordica charantia) - This plant has a long history of use as a hypoglycemic agent and has been referred to as vegetable insulin. At least three properties of Bitter Melon have been reported to have sugar-regulating properties.
Many famous athletes and professional people suffer with type 1 diabetes. It is possible to live a normal life as long as you follow your treatment plan, get daily exercise, eat a healthy diet, and monitor your blood sugar. Ask your doctor about natural remedies that will help you keep your glucose levels in check and aid you in your quest for good health.
All Diabetes Are Not the Same
Posted by admin in Prescription Diabetes Drugs on April 30th, 2011
In my previous article I helped you better understand the problems and solutions of diabetes type 1. Unfortunately, many Americans suffer from another type of diabetes that is far more prevalent and this article will help you better comprehend the differences. Here’s a general description on the two types:
Diabetes falls into the category of metabolic diseases characterized by high blood sugar levels. Under normal conditions, blood glucose levels are controlled by insulin, a hormone produced by the pancreas, the organ responsible for sugar control. All types of diabetics have difficulty either producing too much or not enough. Here is the difference between type 1 and type 2 diabetes in a nutshell.
Type 1 diabetes is sometimes called juvenile diabetes and occurs when the pancreas stops producing insulin. Nobody knows exactly why this happens, but some experts believe a virus or an autoimmune response, in which the body attacks its own pancreatic cells, is responsible. People with this type of diabetes must take insulin for life.
Type 2 was once known as adult-onset and those affected are noninsulin-dependent. In the case of type 2 diabetes, the pancreas secretes plenty of insulin, but the body’s cells don’t respond to it.
Age, Gender, and Obesity Linked to Type 2 Diabetes
Did you know that men, aged 35 to 54 are almost twice as likely to have diabetes as women Recent studies indicate that although diabetes occurs in people of all ages and races, some groups have a higher risk for developing the disease. What researchers don’t know is why certain people develop type 2 diabetes and others do not.
What medical reports do tell us are the factors that increase a person’s risk of getting type 2 diabetes. Let’s take a look at the relationship of type 2 diabetes and three very important characteristics that put you in danger of developing the disease.
Weight - The more fatty tissue you have, the more resistant your cells become to insulin.
Inactivity - Physical activity helps you control your weight, uses up glucose as energy and makes your cells more sensitive to insulin.
Age - The risk of type 2 diabetes increases as you get older, especially after age 45. It may be because as people age they tend to become less active, lose muscle tone and gain unwanted weight.
Its no wonder these common risk factors have sparked concern among members of the medical profession.
More Staggering Statistics
You might agree that it seems more and more people you know are becoming a statistic; one more victim of diabetes 2. I’d like to share a few facts about this fast growing disease that might be of interest to you.
Type 2 diabetes is the most common form and is responsible for 90% - 95% of the 21 million people afflicted with the disease.
People over 40 are at higher risk of the condition, as are people with a large waist or family history of the disease.
Type 2 diabetes is the form linked to poor exercise and diet. Many of the two million people with type 2 are overweight or obese - and an estimated 500,000 more people have type 2 but do not know it.
The number of obese people will increase in the coming decades, putting people at higher risk of heart disease, stroke and certain types of cancer.
Type 2 diabetes can be undetected for a decade or longer and many already have complications by the time it is diagnosed. These complications include heart disease, stroke, kidney failure, blindness and amputation.
The News Is Not All Bad
If you have been diagnosed with type 2 diabetes it might seem frightening at first. But don’t let it get you down. Although type 2 diabetes is serious, it is also manageable. If you are willing to follow a healthy life style you can reduce your risk of developing the disease as well as learn to control it. Consider this:
Losing weight can reduce the risk of type 2 diabetes in high-risk people by 58 percent.
Exercising can cut the risk by 64 percent.
There are also natural remedies for type 2 diabetes that are being explored in addition to standard treatment. Make sure that you inform your doctor about any herbs, supplements, or natural treatments you are taking to safeguard against adverse reactions with other medications.
Diabetes Improves With Natural Minerals
Chromium is a mineral that helps increase the efficiency of insulin, and picolinateis an amino acid that allows the body to use chromium much more readily.
Research shows that chromium picolinate helps lower blood sugar levels in most type 2 diabetics after taking a daily supplement containing the mineral. What’s even better is chromium picolinate has shown to reduce obesity which means it may enable some people with type 2 diabetes to lose enough weight to stop taking drugs entirely.
Magnesium is a mineral that can be found naturally in green leafy vegetables, nuts, seeds, and whole grains. It is needed to help regulate blood sugar levels as well as other bodily functions. Some studies suggest that magnesium supplementation may improve insulin sensitivity and lower fasting glucose levels.
Zinc is important to type 2 diabetics because it helps in the production and storage of insulin. It can be found naturally in oysters, ginger root, lamb, pecans, split peas, egg yolk, rye, beef, liver, lima beans, almonds, walnuts, sardines, and chicken.
Vanadium can be found in soil and many foods and has been found to improve insulin and reduce blood sugar. It actually imitates the action of insulin in the body.
It’s not hard to see why nutritional supplements can be an aid to a diabetic sufferer. However, all diabetics are not created equal. Cases differ in terms of the severity, prescribed medication, diet, and exercise. That’s why I stress the importance of working with a qualified health care professional to find the best treatment and supplement for you.
Posted by admin in Prescription Diabetes Drugs on April 30th, 2011
The anti-diabetes drug rosiglitazone is associated with an increased risk for new-onset heart failure (HF) but no increase in acute coronary events as compared with traditional glucose-lowering drugs, post hoc analyses of the RECORD trial indicate.
The new data lay to rest one safety concern associated with rosiglitazone therapy, but confirm and solidify another, according to investigators speaking at the European Society of Cardiology annual meeting in Barcelona, Spain.
John McMurray (University of Glasgow, UK), an investigator in the RECORD trial, told MedWire News: “My personal belief is that you should not give [glitazones] to anyone with HF or structural heart disease.
“The big question mark ” the really important thing ” is what do you do in other patients, who don’t have a background of heart injury or dysfunction. Are [glitazones] even safe in them “
The first analysis, a study into the effect of rosiglitazone on HF events in the RECORD (Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of glycemia in Diabetes) trial, was presented at a Clinical Trial Update session on Sunday by Michel Komajda (Universite Pierre et Marie Curie, Paris, France). The main study results were published in June 2009.
The post hoc analysis was undertaken in view of previous reports linking thiazolidinediones with an increased risk for HF. In particular, a meta-analysis found that thiazolidinedione therapy conferred a 72% increase in relative risk for HF versus control.
However, some diabetologists questioned the significance of the “HF” observed in the trials included in the meta-analysis, suggesting that it was not “real” HF but fluid retention, which is a known and relatively harmless side-effect of rosiglitazone therapy.
RECORD was a large, long-term, randomized, open-label clinical trial involving 4447 patients aged 40 “75 years who had Type 2 diabetes mellitus and were on metformin or sulfonylurea monotherapy. All participants were free of HF at baseline.
Metformin-treated patients were randomly assigned to receive add-on rosiglitazone or sulfonylurea (and continued metformin), while sulfonylurea-treated patients were randomly assigned to receive add-on rosiglitazone or metformin (and continued sulfonylurea).
The average duration of follow-up was 5.5 years. During this time, there were a total of 29 fatal and nonfatal HF events in the metformin/sulfonylurea treatment groups versus 61 in the rosiglitazone groups. Fatal HF events accounted for two and 10 events in the metformin/sulfonylurea and rosiglitazone groups, respectively.
Komajda revealed that study participants taking rosiglitazone had a more than two-fold greater risk for developing HF than patients in the other treatment groups (hazard ratio [HR]=2.10, p=0.001).
Kaplan-Meier curves showed that the increased HF risk associated with rosiglitazone became apparent early in the trial and continued to increase over time.
Komajda noted that the risk for HF was similar in patients with and without prior ischemic heart disease, although the absolute risk was greater in the former group.
In multivariate analysis, significant baseline predictors of HF were rosiglitazone treatment (HR=2.25); age 60 years (HR=3.81); waist circumference 104 cm (HR=3.52); presence of microalbuminuria or proteinuria (HR=3.35); and use of beta blockers (HR=1.86).
“Overall, these findings support the current recommendation that rosiglitazone should not be used in patients with symptomatic HF or with a history of HF,” Komadja concluded.
In comments to MedWire News, McMurray said that the new data were important because they laid to rest any notion that the fluid retention observed in rosiglitazone-treated patients was harmless.
“It is a legitimate concern and shouldn’t be diminished as something unimportant or benign,” he said. “The conclusion is that glitazones do cause HF, it is real HF, in other words, it is the syndrome that we know carries a very poor prognosis,” he said.
McMurray presented a second post hoc analysis of RECORD at Monday’s Clinical Trial Update session. This followed a controversial meta-analysis that found a 43% increased risk for myocardial infarction (MI) versus control.
The prevalence of ischemic heart disease in the RECORD trial was 15 “20%, McMurray reported, although patients with a recent major CV event or planned CV intervention were excluded.
As already revealed in the main study report, the risk for suffering a first fatal or nonfatal MI did not differ significantly between the two study groups (HR=1.14). According to new data presented on Monday, outcomes following nonfatal MI were also comparable between the treatment groups, with similar rates of recurrent MI and unstable angina.
In the overall study population, the rosiglitazone and metformin/sulfonylurea groups had comparable risks for developing the following: acute coronary syndromes (ACS, HR=1.05); ACS or “other” hospitalization attributed to angina pectoris (HR=0.99); and ACS, other angina hospitalization, or coronary revascularization (HR=0.94).
McMurray ended his presentation by showing an analysis of total cardiovascular events, which revealed no difference between the treatment groups with regard to death, hospital admission, or revascularization. There were a total of 221 such events (in 127 patients) in the rosiglitazone groups and 230 events (in 128 patients) in the metformin/sulfonylurea groups.
He concluded: “In the RECORD trial, there was no statistically significant excess of ‘first’ MI, unstable angina, or other coronary outcomes in subjects treated with rosiglitazone plus metformin or a sulfonylurea compared to those treated with the combination of metformin plus a sulfonylurea.”
A third post hoc analysis of RECORD has also been performed, McMurray noted. This focused on the risk for bone fractures and confirms other studies showing that there is an increased risk for fractures in rosiglitazone-treated patients. The analysis will be presented at a future meeting.
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009
