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Prescription Diabetes Drugs
FTO variant associated with atherogenic lipid profile, increased MI risk]]>
Posted by admin in Prescription Diabetes Drugs on June 22nd, 2011
The risk allele for the common fat mass and obesity-associated gene (FTO) variant predisposes carriers to a more atherogenic lipid profile and increased risk for myocardial infarction (MI), say researchers.
Many previous studies have shown that carriers of the A allele of the rs9939609 FTO single nucleotide polymorphism (SNP) have increased body fat and risk for Type 2 diabetes compared with noncarriers.
As reported in the journal Circulation: Cardiovascular Genetics, Colin Palmer and colleagues from the University of Dundee in the UK assessed the influence of the rs9939609 genotype on lipid levels and risk for MI in 4897 participants with Type 2 diabetes of the Genetics of Diabetes Audit and Research Study in Tayside Scotland study (Go-DARTS).
They found that carriers of the A allele had 0.03 mmol/l (1.16 mg/dl) lower high-density lipoprotein (HDL) DHDLHHhhh HHHh;yivgcholesterol, 0.10 mmol/l (8.86 mg/dl) higher triglycerides, than non carriers.
In addition, during an average follow-up of 3.6 years more A allele carriers had fatal or nonfatal MI than noncarriers at 8.44% (230 events) versus 6.82% (94 events).
Overall, A allele carriers were twice as likely to experience MI compared with noncarriers after adjustment for potential confounding factors.
Of note, statin use appeared to completely remove the additional cardiovascular risk experienced by A allele carriers compared with TT homozygotes.
“We have demonstrated in a large group of patients with Type 2 diabetes that the A allele of rs9939609 in the FTO gene is associated not only with a raised body mass index but also with a tendency to a dyslipidemic phenotype seen typically in the insulin resistance [metabolic] syndrome,” conclude Palmer and co-authors.
“This variant may, therefore, in the future contribute to more effective targeting of specific preventative therapy.”
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009
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