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Prescription Diabetes Drugs
Posted by admin in Prescription Diabetes Drugs on October 08th, 2009
Researchers have identified several candidate genes and loci associated with variation in the acute insulin response to glucose (AIRg), including those involved in phosphorylation and ion transport.
Genetic factors play an important role in an individual’s risk for developing Type 2 diabetes. Stephen Rich (University of Virginia, Charlottesville, Virginia, USA) and co-workers attempted to identify genes and regions in the human genome that are associated with the AIRg, a direct measure of beta-cell response and an important predictor of Type 2 diabetes.
The team performed a two-stage genome-wide association scan to analyze single nucleotide polymorphisms (SNPs) in Hispanic-American participants from the Insulin Resistance Atherosclerosis Family Study.
In the first stage, 317K SNPs were assessed in 229 Hispanic-American DNA samples from participants without Type 2 diabetes who had complete data for glucose homeostasis and obesity phenotypes available.
A total of 1536 SNPs with evidence of association were chosen for genotyping in the 1190 Hispanic samples for which glucose homeostasis data were available.
The researchers identified multiple regions of the human genome as likely to harbor genes contributing to variation in AIRg.
No individual SNP achieved genome-wide levels of significance, the authors report in the journal Diabetologia. However, “two regions, 6p21 and 20p11, were notable in having associations at more than one SNP,” they write.
Additional genotyping in these regions highlighted several candidate genes that may contribute to variation in AIRg. These included a gene desert in chromosome 6p21 (containing PXT1, KCTD20, and STK38) and several genes in chromosome 20p11 (ENTPD6, PYGB, GINS1, and RP4-691N24.1).
“The latter series of genes suggests a mechanism of action that could be involved in phosphorylation and ion transport,” note the authors.
The genes and loci identified in this study explain a small component of variation in AIRg. “The genes identified are involved in phosphorylation and ion transport, and provide preliminary evidence that these processes are important in beta cell response,” conclude the authors.
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009
